Forschung der Gynäkologie

Characteristics and survival of primary vaginal malignancy: an analysis of the German nationwide cancer registry data.


Forner DM. (2022)

Background: Vaginal neoplasms are rare. To study the survival of patients depending on tumour characteristics and age, the data from the national cancer registries in Germany were analysed.

Methods: In a retrospective analysis, data from 2006 to 2015 on disease stage, survival, and factors that might affect prog-nosis were analysed.

Results: Altogether, out of 4004 datasets, 2194 were deemed adequate to be included in the analysis. Overall survival at 5 years (5YSR) and relative survival (5RSR) were 48.6% (95%CI 45.4–52.1%) and 58.7% (95%CI 55.3–61.2%) for carcino-mas, but significantly worse at 20.2% (95%CI 8.3–32.0%) and 24.2% (95%CI 16.4–32.0%) for melanomas and 38.3% (95%CI 23.3–53.5%) and 44.4% (95%CI 31.5–56.8%) for sarcomas. 5YSR and 5RSR correlated significantly with FIGO stages (5YSR: 66.9–10.1%; 5RSR: 81.7–11.9%, p =0.04). Furthermore, survival depended on the absence of LN metastases (5RSR: 59.1% vs. 38.0%, p < 0.001), and the tumour grading had an influence (5RSR: 83.7–52.1%). We also noted that prognosis was worse for older patients ≥75 years (5RSR:51.2%) than for patients <55 years (62.2%) and 55–74 years of age (61.6%).

Conclusion: Unless LN metastases, local advanced tumours and G3 grading are associated with a worse prognosis. Relative survival of older patients decreases, perhaps indicating that treatment compromises have been made.

Keywords: Vaginal cancer | Epidemiology | Survival | Age

J Cancer Res Clin Oncol. 2022 Mar 21. doi: 10.1007/s00432-022-03982-7. Epub ahead of print. PMID: 35314872

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